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推荐工具
蛋白-蛋白对接

蛋白-蛋白复合物三维结构预测工具,为蛋白质结构功能研究提供线索。

抗原-抗体对接

基于深度学习算法的抗原-抗体复合物三维结构预测工具,根据三维结构提供界面接触残基信息及能量贡献,为CDR优化等提供线索。

蛋白-小分子对接

基于深度学习算法的蛋白-小分子复合物三维结构预测工具,根据三维结构可获得化合物与特定残基的相互作用信息,为小分子的结构优化提供线索。

虚拟筛选

基于深度学习算法的虚拟筛选工具,快速筛选化学多样性小分子库,获得潜在活性分子列表。

反向对接(潜在靶标预测)

给定目标分子,筛选内置靶标结构库,获得该分子可能结合的潜在靶标。

基于特定疾病的分子对接

根据特定疾病可选择该疾病相关的内置靶标,针对部分或所有该疾病相关的靶标进行分子对接。

基于信号通路的分子对接

根据信号通路可选择该通路相关的内置靶标,针对部分或所有该通路相关的靶标进行分子对接。

自定义靶标集的分子对接

用户可建立自定义的靶标集,针对部分或所有自定义靶标集进行分子对接。

PROTAC三元体结构预测与linker设计

预测靶蛋白(POI)、E3连接酶、PROTAC三元体复合物三维结构,评估不同长度linker片段形成PROTAC分子的合理性。

服务

分子模拟与CADD服务

  • PROTAC三元体复合物结构预测与linker设计
  • 蛋白结构模建与相互作用预测
  • 虚拟筛选
  • 药效团与基于深度学习算法的QSAR模型构建
  • MD模拟与结合自由能计算
  • 聚类、相似性搜索等化学信息学分析

生化与细胞实验服务

  • MTT、CCK8法细胞生长曲线测定
  • 细胞侵袭、迁移实验,平板克隆实验
  • 稳转细胞系构建
  • 细胞周期或凋亡
  • Real-Time PCR, WB
  • 蛋白稳定性测定、Kd测定
合作伙伴

我们将开创药物发现算法平台新纪元

2024

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System Error

[2] ErrorException in Cookie.php line 97

Cannot modify header information - headers already sent by (output started at /www/wwwroot/pmr/runtime/classmap.php:1)

  1. }
  2. $name = $config['prefix'] . $name;
  3. // 设置cookie
  4. if (is_array($value)) {
  5. array_walk_recursive($value, 'self::jsonFormatProtect', 'encode');
  6. $value = 'think:' . json_encode($value);
  7. }
  8. $expire = !empty($config['expire']) ? $_SERVER['REQUEST_TIME'] + intval($config['expire']) : 0;
  9. if ($config['setcookie']) {
  10. setcookie($name, $value, $expire, $config['path'], $config['domain'], $config['secure'], $config['httponly']);
  11. }
  12. $_COOKIE[$name] = $value;
  13. }
  14. /**
  15. * 永久保存Cookie数据
  16. * @param string $name cookie名称
  17. * @param mixed $value cookie值
  18. * @param mixed $option 可选参数 可能会是 null|integer|string

Call Stack

  1. in Cookie.php line 97
  2. at Error::appError(2, 'Cannot modify header...', '/www/wwwroot/pmr/thi...', 97, ['name' => 'lang', 'value' => 'index', 'option' => null, ...])
  3. at setcookie('lang', 'index', 0, '/', '', false, '') in Cookie.php line 97
  4. at Cookie::set('lang', 'index', null) in helper.php line 339
  5. at cookie('lang', 'index') in ControllerBase.php line 37
  6. at ControllerBase->_initialize() in Controller.php line 56
  7. at Controller->__construct() in IndexBase.php line 21
  8. at IndexBase->__construct()
  9. at ReflectionClass->newInstanceArgs([]) in App.php line 243
  10. at App::invokeClass('app\index\controller...') in Loader.php line 420
  11. at Loader::controller('index', 'controller', false, 'Error') in App.php line 367
  12. at App::module(['index', 'index', 'index'], ['app_namespace' => 'app', 'app_debug' => true, 'app_trace' => false, ...], true) in App.php line 130
  13. at App::run() in start.php line 18
  14. at require('/www/wwwroot/pmr/thi...') in public.php line 19
  15. at require('/www/wwwroot/pmr/pub...') in index.php line 12

Exception Datas

Error Context
name lang
value index
option Resource
config { "prefix": "", "expire": 0, "path": "\/", "domain": "", "secure": false, "httponly": "", "setcookie": true }
expire 0

Environment Variables

GET Data
empty
POST Data
empty
Files
empty
Cookies
empty
Session
empty

Server/Request Data

USER
www
HOME
/home/www
HTTP_ACCEPT_ENCODING
br,gzip
HTTP_ACCEPT_LANGUAGE
en-US,en;q=0.5
HTTP_ACCEPT
text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8
HTTP_USER_AGENT
CCBot/2.0 (https://commoncrawl.org/faq/)
HTTP_HOST
pumeirui.com
PATH_INFO
/index/index/lang/index.html
REDIRECT_STATUS
200
SERVER_NAME
pumeirui.com
SERVER_PORT
443
SERVER_ADDR
172.26.117.16
REMOTE_PORT
54450
REMOTE_ADDR
44.211.24.175
SERVER_SOFTWARE
nginx/1.17.3
GATEWAY_INTERFACE
CGI/1.1
HTTPS
on
REQUEST_SCHEME
https
SERVER_PROTOCOL
HTTP/2.0
DOCUMENT_ROOT
/www/wwwroot/pmr/public
DOCUMENT_URI
/index.php
REQUEST_URI
/index/index/lang/index.html
SCRIPT_NAME
/index.php
CONTENT_LENGTH
CONTENT_TYPE
REQUEST_METHOD
GET
QUERY_STRING
s=/index/index/lang/index.html
SCRIPT_FILENAME
/www/wwwroot/pmr/public/index.php
FCGI_ROLE
RESPONDER
PHP_SELF
/index.php
REQUEST_TIME_FLOAT
1731296513.9653
REQUEST_TIME
1731296513
Environment Variables
empty

ThinkPHP Constants

BIND_MODULE
index
APP_PATH
/www/wwwroot/pmr/public/../app/
THINK_VERSION
5.0.7
THINK_START_TIME
1731296513.9654
THINK_START_MEM
357240
EXT
.php
DS
/
THINK_PATH
/www/wwwroot/pmr/thinkphp/
LIB_PATH
/www/wwwroot/pmr/thinkphp/library/
CORE_PATH
/www/wwwroot/pmr/thinkphp/library/think/
TRAIT_PATH
/www/wwwroot/pmr/thinkphp/library/traits/
ROOT_PATH
/www/wwwroot/pmr/
EXTEND_PATH
/www/wwwroot/pmr/extend/
VENDOR_PATH
/www/wwwroot/pmr/vendor/
RUNTIME_PATH
/www/wwwroot/pmr/runtime/
LOG_PATH
/www/wwwroot/pmr/runtime/log/
CACHE_PATH
/www/wwwroot/pmr/runtime/cache/
TEMP_PATH
/www/wwwroot/pmr/runtime/temp/
CONF_PATH
/www/wwwroot/pmr/public/../app/
CONF_EXT
.php
ENV_PREFIX
PHP_
IS_CLI
false
IS_WIN
false
QINIU_FUNCTIONS_VERSION
7.1.3
BEHAVIOR_PATH
app\common\behavior\
LAYER_LOGIC_NAME
logic
LAYER_MODEL_NAME
model
LAYER_SERVICE_NAME
service
LAYER_CONTROLLER_NAME
controller
LAYER_VALIDATE_NAME
validate
LAYER_VIEW_NAME
view
RESULT_SUCCESS
success
RESULT_ERROR
error
RESULT_REDIRECT
redirect
RESULT_MESSAGE
message
RESULT_URL
url
RESULT_DATA
data
DATA_STATUS_NAME
status
DATA_NORMAL
1
DATA_DISABLE
0
DATA_DELETE
-1
DATA_SUCCESS
1
DATA_ERROR
0
TIME_CT_NAME
create_time
TIME_UT_NAME
update_time
TIME_NOW
1731296513
SYS_APP_NAMESPACE
app
SYS_HOOK_DIR_NAME
hook
SYS_ADDON_DIR_NAME
addon
SYS_DRIVER_DIR_NAME
driver
SYS_COMMON_DIR_NAME
common
SYS_STATIC_DIR_NAME
static
SYS_VERSION
1.0.0
SYS_ADMINISTRATOR_ID
1
SYS_DS_PROS
/
SYS_DS_CONS
\
SYS_DB_PREFIX
pmr_
SYS_ENCRYPT_KEY
cg#r.Xf<~_:^vui"q;{KV(61s-Lxy=0k8SP?m]A$
PATH_ADDON
/www/wwwroot/pmr/addon/
PATH_PUBLIC
/www/wwwroot/pmr/public/
PATH_UPLOAD
/www/wwwroot/pmr/public/upload/
PATH_PICTURE
/www/wwwroot/pmr/public/upload/picture/
PATH_FILE
/www/wwwroot/pmr/public/upload/file/
PATH_SERVICE
/www/wwwroot/pmr//app/common/service/
PATH_COMMON_LOGIC
app\common\logic\
API_CODE_NAME
code
API_MSG_NAME
msg
DB_LIST_ROWS
15
API_KEY
l2V|gfZp{8`;jzR~6Y1_
JWT_KEY
l2V|DSFXXXgfZp{8`;FjzR~6Y1_
STATIC_DOMAIN
https://cdn.pumeirui.com
IS_POST
false
IS_GET
true
IS_AJAX
false
IS_PJAX
false
IS_MOBILE
false
MODULE_NAME
index
CONTROLLER_NAME
index
ACTION_NAME
index
URL
index/index
URL_TRUE
https://pumeirui.com/index/index/lang/index.html
DOMAIN
https://pumeirui.com
URL_ROOT